What are SARMs?
SARM stands for selective androgen receptor modulators. They are a class of therapeutic compounds. SARMs have recently become popular primarily because they can maintain the desirable effects of androgens. Some examples of these effects include the prevention of osteoporosis, lowering the risk of prostate cancer, preventing muscle mass loss, building lean body mass and muscle growth. Researchers believe that SARMs have the same effect as androgenic drugs, for example, anabolic androgenic steroids. However, they are thought to be more selective in their action, for example, specific tissues. Researchers have been trying to understand if SARMs can replace testosterone supplementation in treating certain diseases. Testosterone supplementation can have adverse effects on patients. Hence liquid SARMs are a popular topic in research right now.
How Do SARMs Work?
Let us try to understand the SARMs mechanism of action before you pop them for muscle growth. When a SARM ligand binds to an androgen receptor (AR), the binding event leads to specific conformational changes. These conformational changes then translate into an alteration of surface topology. The eventual outcome of this is tissue-specific gene regulation. Getting a bit technical here. Well, in simple words, this tissue-specific gene regulation permits selective inhibition or stimulation of the androgenic receptors. It isn’t as simple as it sounds, though; there is an interplay of androgen response elements, transcription factors and co-regulators. Liquid SARMs’ role in increased testosterone production has been studied extensively by researchers. They are also a serious candidate to consider when it comes to losing body fat and averting muscle growth.
How to Take SARMs Properly?
Here is your SARMs guide! Taking SARMs properly without having the essential knowledge is not the wisest course of action. The first thing you need to know about SARMs is that they are available in three different forms. These are raw powdered SARMs, liquid SARMs and pills or powdered SARMs in capsules. You can choose either form for taking SARMs; however, how much you should take is a question that is answered by the type of SARM that you are taking. Liquid SARMs are the most popular type. Also, there are different ways in which you can administer SARMs, for example, sublingual, injectable and nasal sprays. How long are they going to be in your system? Their duration varies from SARM to SARM; we have mentioned the five most common types of SARMs in the next section. Oh, and most of the SARMs require a period of post-cycle therapy!
Since liquid SARMs are the most popular ones, primarily because it is very easy to measure a liquid SARM. First, please measure the dose of your liquid SARMs with a syringe. You can also use an eye dropper for measuring your liquid SARMs. Then, just drink up your liquid SARMs. Yup, that’s all really! Now, we know that liquid SARMs often have a strong taste. So, to mitigate the bitter taste of liquid SARMs, you can take a swig of grapefruit or orange juice. The smell of liquid SARMs is also a bit strong, so to avoid that, you can try holding your breath when taking them, particularly liquid SARM MK-677.
Different Types of SARMs
In this section of the brief, we are going to have a look at different types of SARMS that are currently available in the market.
LGD 4033- Ligandrol
These are a type of SARMs like Ostarine; the only difference is that they are 12 times as powerful as Ostarine. And that too at only 1/3rd of the total dose! Ligandrol has proven its worth as an excellent bulking agent in recent times. Furthermore, its half-life is 24-36 hours. This number implies that you will have to simultaneously take your entire daily dose in one hit.
MK 677- Ibutamoren
A selective of ligand for the growth hormone receptors, Ibutamoren mimics ghrelin’s action. Ghrelin is a hormone involved in the active regulation of appetite in the stomach. However, unlike Ghrelin, this liquid SARM doesn’t raise cortisol levels. In fact, this liquid SARM is an excellent candidate for muscle growth.
MK 2866- Ostarine
Ostarine is one of the most well-known SARMs. The primary function of Ostarine is to preserve muscles in a caloric deficit. It is also known by other names, for example, Enobosarm, and has a half-life of around 24 hours.
RAD 140- Testolone
Since Radarine is a comparatively new SARM, there isn’t much scientific evidence in its favor. However, it has been credited with muscle mass building with lower androgenic side effects. It has a half-life of around 16 hours and has an even more anabolic profile than testosterone.
S4- Andarine
Several benefits are associated with Andarine, the most important of which is that it can increase muscular retention when you are dieting. Then, S4 has also been involved with increased muscle mass; it can also be stacked. When we talk about SARMs for females specifically, then S4 or Andarine is a better option. Also, since its half-life is only 4 hours, it is best to split the liquid SARMs dosage for Andarine.
Conclusion
When taking selective androgen receptor modulators, it is extremely important to have background knowledge about these powerful substances. They have caught everyone’s eye, primarily because of their effect on lean muscle mass and muscle mass production. A lot of hype with respect to increasing lean body mass and lean muscle mass! However, one has to be extremely careful with doses, as inappropriate use can lead to multiple side effects. Remember, they are yet to receive FDA approval, so go easy on them when taking liquid SARMs orally or injecting them!
References
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326857/
https://pubmed.ncbi.nlm.nih.gov/30503797/
