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What are Antiestrogens?

Any drug or chemical that inhibits the production or function of estrogen is known as an antiestrogen. Antiestrogens bring conformational changes in the estrogen receptors (ERs), limiting the hormonal effect and serving as anti-growth factors. 

Estrogen is a hormone that can be both useful and detrimental. It helps keep bones strong by minimizing bone loss and increasing calcium retention. On the other hand, estrogen increases cell proliferation in the breast and uterus, increasing a woman’s risk of developing cancer in both organs.


How Antiestrogens Work?

Antiestrogens attach to the ERs and prevent estrogens from attaching to the target cells. These agents are most frequently used for breast cancer therapy, suppressing estrogen-induced tumour cell proliferation. 

They also help to maximize the benefits of testosterone replacement treatment by ensuring that the body attains an ideal hormonal balance. As a result, estrogen blockers may be necessary for achieving the proper estrogen balance in your body since they work as an antagonist to estrogen receptors such as ERα and Erβ

Antiestrogens are used for estrogen detriment therapy; in infertility, you can also use them to induce ovulation and hormonal replacement therapy.


How to Use Antiestrogens?

Before taking antiestrogens, you should learn about them first. The recommended drug dosage depends on the type of steroid and the medical condition it is administered for. 

You should note that the dosage of antiestrogens for males and women differs significantly. Therefore, to avoid overdose, start with lesser quantities and gradually increase the dosage. 

For bodybuilders and athletes, antiestrogens can be combined with other steroids. For example, you may use Nolvadex antiestrogen with aromatase inhibitors such as Arimidex and Aromasin, which keep the estrogen circulating in the whole body. 

Remember to use antiestrogens only as directed by your doctor. If you use more than the recommended amount, there is a risk of significant adverse effects. Therefore, it’s advisable to talk to your doctor before taking any medication.


Different Types of Antiestrogens

There are different types of antiestrogens that can be used alone or in combination with other steroids to get better results. But, again, it depends on what you are using for which purpose. Some popular antiestrogens are:

  • Arimidex: Arimidex is an estrogen inhibitor. It prevents estrogen levels from growing and testosterone conversion to estrogen. Bodybuilders use Arimidex as an estrogen blocker to boost testosterone levels. The drug can be used in combination with the injectable steroid Faslodex to improve the survival rate in cancer patients.
  • Aromasin: Aromasin contains the bioactive component exemestane. Bodybuilders and gymgoers generally use it to inhibit the effect of estrogen. Aromasin, as previously stated, acts as an inhibitor and prevents androgen esterification
  • Clomid: Clomid affected pituitary gland Gonadotropin and FSH production, which could aid sperm generation and germline cell division. In addition, it is a selective estrogen receptor modulator (SERM) and increases estrogen production and the number of estrogen receptors.
  • Nolvadex: Nolvadex is an ingestible antiestrogen as well as a selective estrogen modulator) (SERM). It helps bodybuilders avoid man boobs, maintain gains, and boost testosterone levels. It is a standard treatment for patients with breast cancer. It prevents the estrogen hormone from attaching to breast tissue, increasing men’s muscle mass without causing gynecomastia (male breasts).


Things to Keep in Mind While Using Antiestrogen

You should use antiestrogen only as directed by your doctor. If you self-medicate and are in abundance, you will likely experience adverse effects. Keep the positive and negative impacts in mind while taking any antiestrogen.

Negative Impacts

  • Affect endocrine glands
  • Some antiestrogens, such as Aromasin, are harmful to a developing baby and should not be used by pregnant or breastfeeding women.
  • Prostate cancer development in case of Clomid if you already have cancer
  • Blur vision and decreased white blood cells count
  • Changes in uterine wall thickening
  • Increased cholesterol levels

Positive Impacts

  • Keep the balance between estrogen and testosterone
  • Maintain muscles gain
  • Fat burning
  • Higher muscle mass and growth 
  • Increased testosterone level
  • Reduced male boobs
  • Better muscle structure


Where to Buy Antiestrogen?

You can buy antiestrogens online in Canada safely and quickly at Online Steroids Canada. Our products are manufactured with the purest ingredients and are produced on-site in controlled conditions. You will never receive low-quality products from us. We monitor all aspects of the supply chain and feel proud about delivering an effective, incredibly SAFE product. 

Want to buy antiestrogens in Canada?


Final Thoughts 

Antiestrogens constitute an essential medical therapy in breast cancer. These diminish the effect of estrogen and prevent cells from multiplying uncontrollably under the hormonal influence. In addition, antiestrogens have found a way in bodybuilding as well. These enhance testosterone levels and beef up muscles and can be combined with injectable steroids.

However, before taking antiestrogens or any drug-altering regular hormone production, we advise talking to your doctor. In addition, people who have medical conditions and are already taking medicines can experience drug interactions with antiestrogens. In that case, self-medication with antiestrogens can lead to more significant problems. Thus if you observe adverse effects, stop taking it and seek medical attention.



Desta, Z., Nguyen, A., Flockhart, D., Skaar, T., Fletcher, R., Weinshilboum, R., et al. (2009). Antiestrogen pathway (aromatase inhibitor). Pharmacogenetics and Genomics, 19(7), 554–55.

Miller, A.B. (1991). Risk/benefit considerations of antiestrogen/estrogen therapy in healthy postmenopausal women. Prev, 20(1), 79-85.

Plourde, P. V., Dyroff, M., & Dukes, M. (1994). Arimidex®: A potent and selective fourth-generation aromatase inhibitor. Breast Cancer Research and Treatment. 30;103–111.

Dank, M. (2002) The role of Aromasin in the hormonal therapy of breast cancer. Pathology Oncology. 8;8.